Creighton snapped a modest two-game losing streak with a win Sunday at home against Georgetown, 80-69. Ryan Kalkbrenner makes the Bluejays go. The 3-time Big East Defensive Player of the Year is averaging 18.7 points, 8.5 rebounds, and 2.8 blocks per game.

The DePaul Blue Demons (11-17, 2-15 Big East) aim to stop a four-game road losing streak when they visit the Creighton Bluejays (19-8, 12-4 Big East) on Wednesday, February 26, 2025 at 9:00 PM ET.

DePaul is in the basement in the Big East alongside Seton Hall with Butler just a tick above with a handful of games remaining this season. The Bulldogs saw their three-game win streak snapped Tuesday at Xavier, 76-63. DePaul has lost four in a row. Their last win was a 74-57 triumph over Seton Hall on February 2.

It’s time to continue our College Basketball odds series with a DePaul-Creighton prediction and pick. Find out how to watch DePaul-Creighton. The Creighton Bluejays are having a good year, but not a great year.

Analyzing Wednesday’s St. John’s at DePaul odds and lines, with college basketball expert picks, predictions and best bets.